Targeting of cancer cells using click-functionalized polymer capsules

MMJ Kamphuis; APR Johnston; GK Such; HH Dam; RA Evans; AM Scott; EC Nice; JK Heath; F Caruso

Journal article

Targeting of cancer cells using click-functionalized polymer capsules

MMJ Kamphuis, APR Johnston, GK Such, HH Dam, RA Evans, AM Scott, EC Nice, JK Heath, F Caruso

Journal of the American Chemical Society | Published : 2010

DOI: 10.1021/ja106405c

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Abstract

Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining targeting molecules with nanoengineered drug carriers, such as polymer capsules, micelles and polymersomes, has significant potential to improve the therapeutic delivery and index of a range of drugs. We present a general approach for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. We demonstrate that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population. This precise targe..

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University of Melbourne Researchers

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Grants

Awarded by NHMRC

Funding Acknowledgements

We thank the ARC and NHMRC for funding under the Federation Fellowship (FF0776078), Discovery Project (DP0877360), and Program Grant (487922) schemes.